Wound dressing that promotes healing

The development of an improved diabetic wound dressing is crucial to the improvement of health in diabetics. 1 in 3 Australians suffer from diabetes and last year over 4000 people died from diabetic wounds that were too inflamed and infected to close over.

Conventional dressing and antibiotics have been deemed ineffective due to the nature of the diabetic wounds. Therefore we endeavoured to create a smart wound dressing biomaterial that would significantly improve the treatment. This novel biomaterial hydrogel constitutes of a polymer called PSA and a protein called albumin. This mixture is in liquid form at room temperature and forms a hydrogel, highly hydrated elastic structure as temperature increases. This behaviour allows for easy handling within the clinics. This hydrogel is also tissue adhesive with ensure that the hydrogel stays in the desired place. This wound dressing biomaterial also stimulates cellular regrowth due to the proteins that we have introduced to the hydrogel. We can also tune the properties of the polymer, making it release certain drugs that can help with inflammation and infection problems. It also possesses a tuneable gelation mechanism, which allows for the use of this biomaterial in both deep tissue and surface dressings. During our experiments we found that the gelation time can be varied from 10 seconds to 2 minutes and the degradation time can also be changed from 5 minutes up to 24 hours. Based on all these results, it is deemed that our method of PSA/Albumin polymer was suitable for diabetic wound dressing/healing.

Oli Lock & Casper Lu

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