The hunt for integrons in on, but will the bacteria prevail, or will they fail? Featured

Ever since the arrival of Penicillin in 1928, there has been major development in other antibiotics to supplement the immune system. Class 1 integrons have played a major role in the global spread of antibiotic resistance which poses a dilemma for the future treatment of bacterial infections.  Imagine a world where a simple infected cut could kill you, it would be devastating!

Quorum’s project is to find new and different integron containing bacteria within horse manure. Integrons are mobile genetic element, segments of DNA capable of migration throughout the host genome which may be transferred to nearby bacteria. Integrons are capable of promoting the antimicrobial resistance genes they contain. They are especially associated with genes conferring antimicrobial resistance, and so are commonly found in resistant bacteria. Exploration of the role of integrons in antibiotic resistance has been a well researched topic throughout the past few decades. (The role of integrons in antibiotic resistance has been the subject of much research over the past few decades.)

 

The horse gut is home to an extremely diverse and crowded microbial ecosystem. Its moist, warm and full of nutrients and while it may not sound so nice to us, bacteria love it. Antibiotics produced by highly competitive bacteria and fungi as well as those given as medicines or included in feed would likely promote a high rate of antibiotic resistance in horse gut bacteria through natural selection by acting as selection pressures. To date, most research regarding integrons has been performed on clinical samples taken from humans, often on a monoculture under specific conditions. Our research aims to look for integrons in a wide range of bacteria in horse manure and form a snapshot of this complex environment, which may open avenues for further research in this area.

 

               

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